Anti-Alpha Synuclein Antibody (2A7)

Name: Anti-Alpha Synuclein Antibody
Brand: PhosphoSolutions
SKU: 108-ASYN
Price: 456.0 USD
Availability: InStock

Our Anti-Alpha Synuclein primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, pig, and rat Alpha Synuclein and is Protein G purified. It is great for use in WB, IHC, ICC.

Western blot of rat brain lysate showing specific immunolabeling of the ~15 kDa alpha synuclein protein.

Immunofluorescence of rat cerebellum showing specific alpha-synuclein staining in synaptic regions in red and GFAP (Cat. 620-GFAP) in the cytoskeleton of glia and astrocytes in green. DNA is stained blue.

Western blot of rat brain lysate showing specific immunolabeling of the ~15 kDa alpha synuclein protein.

Click on image to zoom

Species Reactivity

Bovine, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

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Data Sheet

Trial Size

SKU: 108-ASYN

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Alpha Synuclein

Scientific Background

Alpha-synuclein is a presynaptic neuronal protein that is thought to be involved in the formation of SNARE complexes. Most significantly, aggregated alpha-synuclein is one of the major components found in the Lewy bodies that occur in Parkinson’s disease (PD) and other neurodegenerative disorders (Okochi et al., 2000). Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (ChartierHarlin MC et al., 2004 and Singleton, AB et al., 2005). Alpha-synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).

Format

Protein G Purified

Clonality

Monoclonal

Clone

2A7

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

SNCA

Molecular Weight

15 kDa

Immunogen

Full length human alpha synuclein expressed in E. Coli.

Immunogen Species

Human

Species Reactivity

Bovine, Human, Mouse, Rat

Antibody Registry ID

AB_2889896

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Protein G purified.

Buffer

PBS + 50% glycerol and 5 mm NaN3

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
IHC: 1:1000
ICC: 1:1000

Conjugate

Unconjugated

Specificity

Specific for the endogenous levels of the ~15 kDa alpha synuclein protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Alpha synuclein; Alpha-synuclein; autosomal dominant Lewy body 4; Alpha-synuclein; non A4 component of amyloid precursor; isoform NACP140; alphaSYN; MGC105443; MGC110988; MGC127560; MGC64356; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non-A beta component of AD amyloid; Non-A-beta component of alzheimers disease amyloid; precursor of; Non-A4 component of amyloid precursor; Non-A4 component of amyloid; OTTHUMP00000218549; OTTHUMP00000218551; OTTHUMP00000218552; OTTHUMP00000218553; OTTHUMP00000218554; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant Lewy body 4; Parkinson disease familial 1; SNCA; Snca synuclein alpha (non A4 component of amyloid precursor; SYN; Synuclein alpha; Synuclein alpha 140; Synuclein alpha (non A4 component of amyloid precursor; SYUA_HUMAN; Snca synuclein alpha; Synuclein alpha; Parkinson disease

UniProt ID

P37840
UniProt Summary: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). {ECO:0000269|PubMed:20798282, ECO:0000269|PubMed:26442590, ECO:0000269|PubMed:28288128, ECO:0000269|PubMed:30404828}.

NCBI Gene ID

6622

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Anti-Alpha Synuclein Antibody (2A7)

SKU: 108-ASYN

Product Details

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