Anti-Pan-Neurofascin (Extracellular) Antibody (BSA and Azide free) (A12/18)

Name: Anti-Pan-Neurofascin (Extracellular) Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-172-CF
Price: 486.0 USD
Availability: InStock

Our mouse Pan-Neurofascin (extracellular) carrier-free monoclonal antibody from NeuroMab is produced in-house from clone A12/18. It detects human, non-human primate, and rat Pan-Neurofascin (extracellular) and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Anti-Pan-Neurofascin (Extracellular) Antibody (BSA and Azide free)

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Species Reactivity

Human, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

SKU: 75-172-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Pan-Neurofascin (extracellular)

Scientific Background

Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

A12/18

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Nfasc

Molecular Weight

155, 186 kDa

Immunogen

Lipid raft fractions isolated from adult rat brain. Target identified as Neurofascin (accession number P97685) by: -binding to NF-186-tranfected COS cells- recognition of NF155 and NF186 but not other highly related L1 CAMs like NrCAM- immunoprecipitation of NF155 and NF186 and confirmation by mass spectrometry - loss of immunostaining against NF186-shRNA knockdown samples Rat: amino acids 25-1110 (extracellular domain common to NF155 and NF186);

Immunogen Species

Rat

Species Reactivity

Human, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Neurofascin NF-155 NF-186

UniProt ID

P97685

Shipping

Shipped on ice packs

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Anti-Pan-Neurofascin (Extracellular) Antibody (BSA and Azide free) (A12/18)

SKU: 75-172-CF

Product Details

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