Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate (A12/18)

Name: Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-172-FL490
Price: 499.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

Unconjugated

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Clone

A12/18

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Nfasc

Molecular Weight

155, 186 kDa

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Volume: 200 µL

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Product Details

Target

Pan-Neurofascin (extracellular)

Target Description

Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

A12/18

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Nfasc

Molecular Weight

155, 186 kDa

Antigen

Lipid raft fractions isolated from adult rat brain. Target identified as Neurofascin (accession number P97685) by: -binding to NF-186-tranfected COS cells- recognition of NF155 and NF186 but not other highly related L1 CAMs like NrCAM- immunoprecipitation of NF155 and NF186 and confirmation by mass spectrometry - loss of immunostaining against NF186-shRNA knockdown samples Rat: amino acids 25-1110 (extracellular domain common to NF155 and NF186);

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939632

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Neurofascin NF-155 NF-186

UniProt Details

UniProt (Human): O94856
UniProt (Immunogen Species): P97685

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Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate (A12/18)

Available Conjugates

Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate
SKU: 75-172-FL490

Bulk Order Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate

Product Details

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Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate (A12/18)

Available Conjugates

Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate SKU: 75-172-FL490

Bulk Order Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate

Product Details

Anti-Pan-Neurofascin (Extracellular) Antibody FL490 Conjugate
SKU: 75-172-FL490