Anti-Nav1.1 Na+ Channel Antibody (K74/71)

Name: Anti-Nav1.1 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-023
Price: 394.0 USD
Availability: InStock

Our mouse Nav1.1 Na+ channel monoclonal antibody from NeuroMab is produced in-house from clone K74/71. It detects human, mouse, non-human primate, and rat Nav1.1 Na+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Immunolabeling of Nav1.1 (Cat. 75-023, 1:250) showing an increased expression in the Dorsal Root Ganglia of NaV1.7 knockout mice when compared to control mice. Image from publication. PMID: 39559752.

Adult rat whole brain immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

Trial Size

SKU: 75-023

Volume: 100 µL

Variant

Price:

$394.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Nav1.1 Na+ channel

Scientific Background

Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K74/71

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Scn1a

Molecular Weight

220 kDa

Immunogen

Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2238842

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:500
IHC: 1:250
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity with Nav1.2, Nav1.3 and Nav1.6

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

UniProt ID

P04774

Shipping

Shipped on ice packs

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Anti-Nav1.1 Na+ Channel Antibody (K74/71)

SKU: 75-023

Product Details

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