Anti-Mitofusin-1 Antibody (N111/24)

Name: Anti-Mitofusin-1 Antibody
Brand: NeuroMab
SKU: 75-162
Price: 337.0 USD
Availability: InStock

Our mouse Mitofusin-1 monoclonal antibody from NeuroMab is produced in-house from clone N111/24. It detects mouse and rat Mitofusin-1 and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn2 KO Mfn1 KO mice and probed with N111/24 TC supe. Samples courtesy of Dr. Suzanne Hoppins, Dr. Laura Lackner and Dr. Jodi Nunnari, UCDavis.

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-162

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Mitofusin-1

Scientific Background

Mitofusin 1, or transmembrane GTPase Mfn1 (MFN1) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria in many tissues, including heart and testis. Diseases associated with MFN1 include Optic Atrophy 1 and Autosomal Recessive Spastic Paraplegia .

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N111/24

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Mfn1

Molecular Weight

80 kDa

Immunogen

Fusion protein amino acids 350-580 of mouse Mitofusin-1 (accession number Q811U4) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2266317

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.88

Conjugate

Unconjugated

Specificity

No cross-reactivity against Mitofusin-2

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Mitofusin-1 (EC 3.6.5.-) (Transmembrane GTPase MFN1)

UniProt ID

Q811U4

Shipping

Shipped on ice packs

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Anti-Mitofusin-1 Antibody (N111/24)

SKU: 75-162

Product Details

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