Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody FL594 Conjugate (N75/33)

Name: Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody FL594 Conjugate
Brand: NeuroMab
SKU: 75-116-FL594
Price: 486.0 USD
Availability: InStock

Our mouse mGluR1/5 (Group I) glutamate receptor FL594 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N75/33. It detects human, mouse, and rat mGluR1/5 (Group I) glutamate receptor and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody FL594 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-116-FL594

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

mGluR1/5 (Group I) glutamate receptor

Scientific Background

The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N75/33

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Grm5 Gprc1e Mglur5

Molecular Weight

130 kDa (both mGluR1 and mGluR5)

Immunogen

Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (accession number P31424) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939434

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

Recognizes mGluR1 and mGluR5

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Metabotropic glutamate receptor 5 (mGluR5)

UniProt ID

P31424

Shipping

Shipped on ice packs

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Anti-mGluR1/5 (Group I) Glutamate Receptor Antibody FL594 Conjugate (N75/33)

SKU: 75-116-FL594

Product Details

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