The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
IHC, IP, WB
Grm5 Gprc1e Mglur5
130 kDa(both mGluR1 and mGluR5)
Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (also known as metabotropic glutamate receptor 5, accession number P31424); Mouse: 96% identity (368/388 amino acids identical); Human: 87% identity (339/388 amino acids identical); Less than 35% identity with mGluR1
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Recognizes mGluR1 and mGluR5
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.