Anti-MECP2 Antibody FL490 Conjugate (N227/21)

Name: Anti-MECP2 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-273-FL490
Price: 486.0 USD
Availability: InStock

Our mouse MECP2 FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N227/21. It detects human, mouse, and rat MECP2 and is purified by Protein A chromatography. Works in IHC.

Anti-MECP2 Antibody FL490 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-273-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

MECP2

Scientific Background

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N227/21

Isotype

IgG1

Applications

IHC

Host Species

Mouse

Gene Name

MECP2

Molecular Weight

75 kDa

Immunogen

Synthetic peptide amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2 (accession number P51608)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939980

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Reacts preferentially with dimethylated peptide than with unmethylated peptide

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

UniProt ID

P51608

Shipping

Shipped on ice packs

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Anti-MECP2 Antibody FL490 Conjugate (N227/21)

SKU: 75-273-FL490

Product Details

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