Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998). Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999). RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Purified
1 mg/mL
Monoclonal
N227/21
IgG1
DB, IHC
Mouse
MECP2
Synthetic peptide amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2 (also known as Methyl-CpG-binding protein 2, accession number P51608); Mouse: 100% identity (13/13 amino acids identical); Rat: 100% identity (13/13 amino acids identical)
Human, Mouse, Rat
AB_11001583
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Reacts preferentially with dimethylated peptide than with unmethylated peptide
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from opening
Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
