Anti-Kvbeta1.2 K+ Channel Antibody (K47/42)

Name: Anti-Kvbeta1.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-019
Price: 337.0 USD
Availability: InStock

Our mouse Kvbeta1.2 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone K47/42. It detects mouse and rat Kvbeta1.2 K+ channel and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.

$Immunoblot of crude membrane fractions from adult heart ventricle (V) and brain (B) from wild-type (WT) and Kvß1 knockout (Kvβ1) mice probed with K47/42 (Kvβ1.2, top) and K17/70 (Kvβ2, bottom). Data courtesy of Jeanne Nerbonne, Washington University SOM. Reproduced with permission from 2005 Aimond et al. Circ Res.$

Adult rat hippocampus immunohistochemistry.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K37/89 (left) or N52A/42 (right) TC supe.$

Immunoblot of crude membrane fractions from adult heart ventricle (V) and brain (B) from wild-type (WT) and Kvß1 knockout (Kvβ1) mice probed with K47/42 (Kvβ1.2, top) and K17/70 (Kvβ2, bottom). Data courtesy of Jeanne Nerbonne, Washington University SOM. Reproduced with permission from 2005 Aimond et al. Circ Res.

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-019

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kvbeta1.2 K+ channel

Scientific Background

Voltage-gated potassium channel subunit beta-1 or Kvβ1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvβ1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K47/42

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

KCNAB1 KCNA1B

Molecular Weight

65 kDa

Immunogen

Synthetic peptide amino acids 9-28 (ADIPSPKLGLPKSSESALKC, unique Nterminus) of human Kv1.2 (accession number NP_003462)

Immunogen Species

Human

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_10674579

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1)

UniProt ID

Q14722-3

Shipping

Shipped on ice packs

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Anti-Kvbeta1.2 K+ Channel Antibody (K47/42)

SKU: 75-019

Product Details

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