Anti-Kv3.4 K+ Channel Antibody (BSA and Azide free) (N72/16)

Name: Anti-Kv3.4 K+ Channel Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-112-CF
Price: 486.0 USD
Availability: InStock

Our mouse Kv3.4 K+ channel carrier-free monoclonal antibody from NeuroMab is produced in-house from clone N72/16. It detects C. elegans, human, mouse, and rat Kv3.4 K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Anti-Kv3.4 K+ Channel Antibody (BSA and Azide free)

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Species Reactivity

C. elegans, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

SKU: 75-112-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv3.4 K+ channel

Scientific Background

Potassium voltage-gated channel subfamily C member 4 or Kv3.4 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.4 is primarily expressed in brain and found in the cerebellum, hippocampus, brain stem and spinal cord. It has also been found in skeletal and arterial smooth muscle. Kv3.4 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc4) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy. Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease and has been implicated in chronic hypoxia and Parkinson’s disease.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

N72/16

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc4

Molecular Weight

70 kDa (100 kDa in brain due to glycosylation)

Immunogen

Synthetic peptide amino acids 175-192 (GDEAGDDERELALQRLGP) of rat Kv3.4 (accession number Q63734)

Immunogen Species

Rat

Species Reactivity

C. elegans, Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4)

UniProt ID

Q63734

Shipping

Shipped on ice packs

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Anti-Kv3.4 K+ Channel Antibody (BSA and Azide free) (N72/16)

SKU: 75-112-CF

Product Details

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