Immunoblot against crude C. elegans worm extracts and brain membranes from adult rat (RBM) probed with N72/16 TC supe.
Anti-Kv3.4 K+ Channel Antibody
Kv3.4 K+ channel
Potassium voltage-gated channel subfamily C member 4 or Kv3.4 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.4 is primarily expressed in brain and found in the cerebellum, hippocampus, brain stem and spinal cord. It has also been found in skeletal and arterial smooth muscle. Kv3.4 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc4) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy. Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease and has been implicated in chronic hypoxia and Parkinson’s disease.
IHC, IP, WB
70 kDa(100 kDa in brain due to glycosylation)
Synthetic peptide amino acids 175-192 (GDEAGDDERELALQRLGP) of rat Kv3.4 (also known as potassium voltage-gated channel subfamily C member 4 and Raw3, accession number Q63734); Mouse: 100% identity (18/18 amino acids identical); Human: 94% identity (17/18 amino acids identical)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4)