Anti-Kv3.4 K+ Channel Antibody (N72/16)

Name: Anti-Kv3.4 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-112
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnc4

Molecular Weight

70 kDa(100 kDa in brain due to glycosylation)

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Immunoblot against crude C. elegans worm extracts and brain membranes from adult rat (RBM) probed with N72/16 TC supe.

Adult rat hippocampus immunohistochemistry.

Adult rat whole brain immunohistochemistry.

Adult rat cerebellum immunohistochemistry.

Immunoblot against crude C. elegans worm extracts and brain membranes from adult rat (RBM) probed with N72/16 TC supe.

Product Details

Target

Kv3.4 K+ channel

Target Description

Potassium voltage-gated channel subfamily C member 4 or Kv3.4 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.4 is primarily expressed in brain and found in the cerebellum, hippocampus, brain stem and spinal cord. It has also been found in skeletal and arterial smooth muscle. Kv3.4 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc4) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy. Kv3.4 is also over-expressed in the early stages of Alzheimer’s disease and has been implicated in chronic hypoxia and Parkinson’s disease.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N72/16

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnc4

Molecular Weight

70 kDa(100 kDa in brain due to glycosylation)

Antigen

Synthetic peptide amino acids 175-192 (GDEAGDDERELALQRLGP) of rat Kv3.4 (also known as potassium voltage-gated channel subfamily C member 4 and Raw3, accession number Q63734); Mouse: 100% identity (18/18 amino acids identical); Human: 94% identity (17/18 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673277

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4)

UniProt Details

UniProt (Human): Q03721
UniProt (Immunogen Species): Q63734

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Anti-Kv3.4 K+ Channel Antibody (N72/16)

Anti-Kv3.4 K+ Channel Antibody
SKU: 75-112

Product Details

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Anti-Kv3.4 K+ Channel Antibody (N72/16)

Anti-Kv3.4 K+ Channel Antibody SKU: 75-112

Product Details

Anti-Kv3.4 K+ Channel Antibody
SKU: 75-112