Anti-Kv2.1 Potassium Channel Subunit Antibody Biotin Conjugate (L80/21)

Name: Anti-Kv2.1 Potassium Channel Subunit Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-315-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv2.1 potassium channel subunit biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone L80/21. It detects human, mouse, and rat Kv2.1 potassium channel subunit and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB.

Anti-Kv2.1 Potassium Channel Subunit Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-315-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv2.1 potassium channel subunit

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

L80/21

Isotype

IgG3

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Immunogen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt ID

P15387

Shipping

Shipped on ice packs

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Anti-Kv2.1 Potassium Channel Subunit Antibody Biotin Conjugate (L80/21)

SKU: 75-315-BTN

Product Details

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