Anti-Kv2.1 Potassium Channel Subunit Antibody (L80/21)

Name: Anti-Kv2.1 Potassium Channel Subunit Antibody
Brand: NeuroMab
SKU: 75-315
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

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Adult rat hippocampus immunohistochemistry.

Immunoblot against crude brain membranes from adult rat (RBM) and Kv2.1 wild-type (WT) or knockout (KO) mouse probed with L80/21 (left) or N52A/42 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Product Details

Target

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

Target Description

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L80/21

Isotype

IgG3

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Antigen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (also known as Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Kcnb1 and Shab, accession number P15387) Mouse: 100% identity (17/17 amino acids identical) Human: 88% identity (15/17 amino acids identical, RVLPGGGAHGSTRDQSI)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315863

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt Details

UniProt (Human): Q14721
UniProt (Immunogen Species): P15387

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Anti-Kv2.1 Potassium Channel Subunit Antibody (L80/21)

Anti-Kv2.1 Potassium Channel Subunit Antibody
SKU: 75-315

Product Details

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Anti-Kv2.1 Potassium Channel Subunit Antibody (L80/21)

Anti-Kv2.1 Potassium Channel Subunit Antibody SKU: 75-315

Product Details

Anti-Kv2.1 Potassium Channel Subunit Antibody
SKU: 75-315