Anti-Kv2.1 K+ Channel Antibody Biotin Conjugate (K89/34)

Name: Anti-Kv2.1 K+ Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-014-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Kv2.1 K+ channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone K89/34. It detects hamster, human, mouse, non-human primate, and rat Kv2.1 K+ channel and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB, IP.

Anti-Kv2.1 K+ Channel Antibody Biotin Conjugate

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Species Reactivity

Hamster, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

Trial Size

SKU: 75-014-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv2.1 K+ channel

Scientific Background

Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

K89/34

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Immunogen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Immunogen Species

Rat

Species Reactivity

Hamster, Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity against rat Kv2.2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt ID

P15387

Shipping

Shipped on ice packs

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Anti-Kv2.1 K+ Channel Antibody Biotin Conjugate (K89/34)

SKU: 75-014-BTN

Product Details

Bulk Order Anti-Kv2.1 K+ Channel Antibody Biotin Conjugate

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