Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate (K89/34)

Name: Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-014-FL490
Price: 499.0 USD
Availability: InStock

from NeuroMab

KO Validated

Available Conjugates

Unconjugated

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

K89/34

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

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Volume: 200 µL

Variant

Price:

$499

Quantity:

Bulk Order Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate

Product Details

Target

Kv2.1 K+ channel

Target Description

Kv 2.1 K+ channel (Potassium voltage-gated channel subfamily B member 1), which is encoded by KCNB1 gene, is a member of the Potassium voltage-gated channel familly. This protein, mainly expressed in the central nervous system, functions as a delayed rectifier. Indeed, it regulates the action potential (AP) repolarization as well as duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells. Kv2.1 K+ channel switches between open or closed conformation in response to the voltage difference across the membrane. This process directs the voltage-dependent potassium ion permeability of excitable membranes, which lets potassium ions pass in accordance with their electrochemical gradient. Kv2.1 K+ channel is widely used as a marker to measure membrane excitability in hippocampal neurons.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

K89/34

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnb1

Molecular Weight

105-125 kDa (varies with cell background due to phosphorylation)

Antigen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (accession number P15387)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939116

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against rat Kv2.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (Voltage-gated potassium channel subunit Kv2.1)

UniProt Details

UniProt (Human): Q14721
UniProt (Immunogen Species): P15387

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Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate (K89/34)

Available Conjugates

Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate
SKU: 75-014-FL490

Bulk Order Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate

Product Details

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Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate (K89/34)

Available Conjugates

Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate SKU: 75-014-FL490

Bulk Order Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate

Product Details

Anti-Kv2.1 K+ Channel Antibody FL490 Conjugate
SKU: 75-014-FL490