Anti-Kv2.1 K+ Channel Antibody (K89/34)

Our mouse Kv2.1 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone K89/34. It detects hamster, human, mouse, non-human primate, and rat Kv2.1 K+ channel and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.

Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.
Adult rat brain membrane immunoblot.
Adult rat hippocampus immunohistochemistry.
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].
Representative super-resolution Airyscan images taken at a focal plane near the PM of CTL (black) and U18-treated (red) neurons fixed and immunolabeled for KV2.1 (Cat. 75-014). Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from Wild-Type (WT) (black) and NPC1I1061T (red) cortical sagittal sections stained with Hoechst and immunolabeled for KV2.1 (Cat. 75-014, 10ug/ml). Right, quantification of Kv2.1 total intensity, cluster size and cluster density of WT (black) and NPC1I1061T (red) neurons in the soma region. Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from WT (black) and NPC1I1061T (red) mouse cerebellar sagittal sections co-immunolabeled for Calbindin (Cat. 75-448, 2ug/ml) , CaV1.2 (Cat. 75-257, 5ug/ml) and KV2.1 (Cat. 75-014, 10ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative super-resolution TIRF images of CTL (black) and U18-treated (red) neurons co-immunolabeled for CaV1.2 (Cat. 75-257, 5 ug/ml) and KV2.1 (Cat. 75-014, 10 ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative images of astrocytes labeled by AAV5-GfaABC1D-EBFP and neurons labeled by Kv2.1 (Cat. 75-014, 1:100) in the hippocampal CA1sr and VMH. The measurement method of soma diameter is shown on the right. The yellow dashed lines show the three randomly selected branches of each cell. Image from publication CC-BY-4.0. PMID:38137092
Image of cultured hippocampal cells immune-labeled with antibodies specific for Kv2.1 (Cat. 75-014, 1:400; green) and GLT-1 showing a pyramidal cell with a portion of the basal surface in contact with a GLT-1a positive astrocyte. The right panel shows an enlargement of the boxed area. Image from publication CC-BY-4.0. PMID:38362041
Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Click on image to zoom

Hamster, Human, Mouse, Rat
ELISA, ICC, IHC, IP, WB
Mouse
490
550
594
650
Biotin
Carrier-Free

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Data Sheet
KO Validated KO Validated Trial Size Trial Size

SKU: 75-014

Volume: 100 µL
Price:
$394.00
Ships: 1-2 business days

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