Anti-Kir2.1 K+ Channel Antibody (N112B/14)

Name: Anti-Kir2.1 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-210
Price: 337.0 USD
Availability: InStock

Our mouse Kir2.1 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N112B/14. It detects human, mouse, non-human primate, and rat Kir2.1 K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Kir2.1 or untagged Kv2.1 plasmids and probed with N112B/14 (left) and K89/41 (right) TC supe.

Immunostaining for Kir2.1 (red), NaV1.5 (white), and wheat germ agglutinin (WGA; green) in control Male 1 iPSC-CM (left) and Male 1 iPSC-CM transfected with SNTA1. Nuclei were stained with DAPI. Yellow arrows point to iPSC-CM membrane staining. Image from publication CC-BY-4.0. PMID: 35762211

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-210

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kir2.1 K+ channel

Scientific Background

Kir2.1 (KCNJ2) is a member of the inward rectifier potassium ion channel family which also includes Kir2.2 and Kir2.3. Kir2.1 is expressed in the membranes of many tissues, including heart, skeletal muscle, kidney and diffusely distributed throughout the brain. Kir2.1 has a role in cardiac excitability and has been shown to have interactions with CLG4, Interleukin 16 and TRAK2. Defects in Kir2.1 are involved with the diseases long QT syndrome type 7 (also known as andersen-Tawil syndrome), short QT syndrome 3, and Familial Atrial Fibrillation 9.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N112B/14

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnj2 Irk1

Molecular Weight

55 kDa

Immunogen

Synthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of mouse Kir2.1 (accession number P35561)

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_11000720

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity against Kir2.2 or Kir2.3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (Potassium channel, inwardly rectifying subfamily J member 2)

UniProt ID

P35561

Shipping

Shipped on ice packs

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Anti-Kir2.1 K+ Channel Antibody (N112B/14)

SKU: 75-210

Product Details

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