Anti-KChIP3 K+ Channel Antibody (K66/38)

Name: Anti-KChIP3 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-005
Price: 337.0 USD
Availability: InStock

Our mouse KChIP3 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone K66/38. It detects human, mouse, and rat KChIP3 K+ channel and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and KChIP3 KO mouse brains probed with K66/38 (left) and K55/82 (right) TC supe. Mouse samples courtesy of Takeshi Sakurai and Joseph Buxbaum (Mount Sinai School of Medicine).

Adult rat brain immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-005

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

KChIP3 K+ channel

Scientific Background

Kchip3 potassium channel, also known as Kv channel-interacting protein 3, Kcnip3, DREantagonist modulator and Dream is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin or neuronal calcium sensor (NCS) family branch of the EF-hand superfamily. Kchip3 is an integral subunit component of native Kv4 channel complexes that may regulate A-type currents and function as a calcium regulated transcriptional repressor. Kchip3 is detected in brain, specifically in the cortex, thalamus, dentate gyrus and cerebellum and can be found throughout the cell. It is also found in other tissues at low levels. Diseases associated with KCNIP3 include alzheimer disease.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K66/38

Isotype

IgG2a

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnip3 Csen Dream Kchip3

Molecular Weight

34 kDa

Immunogen

Fusion protein amino acids 1-256 (full length) of rat Calsenillin/DREAM/KChIP3 (accession number Q9JM47) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2130257

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:250
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity against rat KChIPs 1,2, 4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)

UniProt ID

Q9JM47

Shipping

Shipped on ice packs

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Anti-KChIP3 K+ Channel Antibody (K66/38)

SKU: 75-005

Product Details

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