ICC IHC WB
Sodium channel protein type 4 subunit alpha or Nav1.4 sodium channel is encoded by the gene SCN4A. Nav1.4 is a member of the voltage gated sodium ion channel family. Nav1.4 is an alpha type, pore-forming subunit. It is expressed in skeletal muscle and functions in muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength. Diseases associated with this gene include forms of myotonia and periodic paralysis disorders.
Fusion protein amino acids 38-236 (exonuclease domain) of human WRN (also known as Werner syndrome ATP-dependent helicase, RecQ-like type 3 DNA helicase, RecQ protein-like 2, RECQ3, RECQL2 and RGD1564788, accession number Q14191)
Mouse: 84% identity (168/198 amino acids identical)
Rat: 84% identity (168/198 amino acids identical)
100% identity with Short isoform
40% identity with other exonucleases and RECQ proteins
Werner syndrome ATP-dependent helicase (EC 220.127.116.11) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)
WRN RECQ3 RECQL2
TC Supernatant: AB_2493096
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.