Vesicular acetylcholine transporter (VaCht), or Solute Carrier Family 18 Member A3 is encoded by the gene Slc18a3 and is a member of the vesicular amine transporter family. VaCht transports acetylcholine into secretory vesicles for release into the extracellular space. VaCht is expressed in major cholinergic cell groups in the peripheral and central cholinergic nervous systems. Diseases associated with SLC18A3 include Myasthenic Syndrome and Presynaptic and Presynaptic Congenital Myasthenic Syndromes.
Fusion protein amino acids 55-125 (first vesicle lumen domain) of rat VAChT (also known as Vesicular acetylcholine transporter, Solute carrier family 18 member 3, Vat and Slc18a3, accession number Q62666)
Mouse: 97% identity (69/71 amino acids identical)
Human: 84% identity (60/71 amino acids identical)
40% identity with VMAT1 and other vesicular transporters
Does not cross-react with VMAT1 or VMAT2
Vesicular acetylcholine transporter (VAChT) (rVAT) (Solute carrier family 18 member 3)
Slc18a3 Vacht Vat
TC Supernatant: AB_2532047
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.