Human Mouse Rat
ICC IHC WB
Fusion protein amino acids 1-361 (full-length) of mouse Thorase (also known as ATPase family AAA domain-containing protein 1 and Atad1, accession number Q9D5T0)
Human: 100% identity (361/361 amino acids identical)
Rat: 99% identity (360/361 amino acids identical)
ATPase family AAA domain-containing protein 1 (EC 220.127.116.11) (Thorase)
TC Supernatant: AB_10673514
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Prendergast J, Umanah GK, Yoo SW, Lagerlöf O, Motari MG, Cole RN, Huganir RL, Dawson TM, Dawson VL, Schnaar RL.. (2014), 'Ganglioside regulation of AMPA receptor trafficking. .' Journal of Neuroscience. 10.1523/JNEUROSCI.1149-14.2014. " "
- Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J.. (), 'Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. .' The EMBO Journal. 10.15252/embj.201487943. " "
- Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL.. (2011), 'The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior. .' Cell. 10.1016/j.cell.2011.03.016. "