Anti-Synaptotagmin-7 Antibody (N275/14)

Name: Anti-Synaptotagmin-7 Antibody
Brand: NeuroMab
SKU: 75-265
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Synaptotagmin-7 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N275/14. It detects mouse and rat Synaptotagmin-7, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Synaptotagmin or untagged Kv2.1 plasmids and probed with N275/14 (left) and N86/8 (right).

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-265

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Synaptotagmin-7

Target Description

Synaptotagmins are a family of calcium sensing, membrane trafficking proteins. 17 different synaptotagmins have been identified in mammals. Synaptotagmin 7 is highly, ubiquitously expressed in the brain and was originally identified as a Ca2+ sensor for lysosomal exocytosis, but has since been demonstrated to play roles in secretion from many different cell types (MacDougall DD, et al., 2018)

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N275/14

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Syt7

Molecular Weight

45 kDa (plus others)

Antigen

Fusion protein amino acids 150-239 (cytoplasmic C2A domain) of mouse Synaptotagmin-7 (accession number Q9R0N7) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_11030371

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Synaptotagmin-6 (or other Synaptotagmins)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Synaptotagmin-7 (Synaptotagmin VII) (SytVII)

UniProt Details

UniProt (Human): O43581
UniProt (Immunogen Species): Q9R0N7

Turecek J1, Jackman SL1, Regehr WG1. (2017), 'Synaptotagmin 7 confers frequency invariance onto specialized depressing synapses..' Nature. . 10.1038/nature24474.

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Anti-Synaptotagmin-7 Antibody (N275/14)

SKU: 75-265

Product Details

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