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Products: Primary Antibodies

Anti-SAPAP1 Antibody (N238/30)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-468
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-468
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC

Target Description:

SAPAP1 (also known as disks large associated protein 1, DAP-1, or DLGAP1) is a member of the SAPAP or DLGAP family of proteins. SAPAP1 is part of the scaffold in neuronal cells of the brain and is a component of the postsynaptic complex. SAPAP1 acts as an adaptor protein that binds synaptic scaffold proteins, cytoskeletal proteins and signaling proteins including PSD-95 and SHANK. SAPAP1 is expressed in neurons of the cortex, hippocampus and in Purkinje cells in the cerebellum. Diseases associated with DLGAP1 include Retinitis Pigmentosa 55 and Obsessive-Compulsive Disorder

Immunogen:

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks largeassociated protein 1, DAP-1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1 and Dlgap1, accession number P97836) Mouse: 99% identity (200/201 amino acids identical)
Human: 99% identity (199/201 amino acids identical)
55-65% identity with other SAPAPs

Protein Name(s):

Disks large-associated protein 1 (SAPAP1) SAPAP-1

Gene Name(s):

DLGAP1 DAP1 GKAP

Antibody Registry ID:

Purified: AB_2722668
TC Supernatant: AB_2636853


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

110 kDa (varies due to post-translational modifications)


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.