Human Mouse Rat
Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (also known as disks largeassociated protein 1, DAP-1, guanylate kinase-associated protein, GKAP, SAP90/PSD-95-associated/binding protein 1 and Dlgap1, accession number P97836)
Mouse: 99% identity (200/201 amino acids identical)
Human: 99% identity (199/201 amino acids identical)
55-65% identity with other SAPAPs
Does not cross-react with other SAPAPs
Disks large-associated protein 1 (SAPAP1) SAPAP-1 Disks large-associated protein 2 (SAPAP2) SAPAP-2
DLGAP1 DAP1 GKAP DLGAP2 C8orf68 DAP2 ERICH1-AS1
TC Supernatant: AB_10671661
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
110 kDa(varies due to post-translational modifications)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Schreiber J, Végh MJ, Dawitz J, Kroon T, Loos M, Labonté D, Li KW, Van Nierop P, Van Diepen MT, De Zeeuw CI, Kneussel M, Meredith RM, Smit AB, Van Kesteren RE.. (2015), 'Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels. .' The Journal of Biology. 10.1083/jcb.201506048. " "
- Lugo JN, Smith GD, Arbuckle EP, White J, Holley AJ, Floruta CM, Ahmed N, Gomez MC, Okonkwo O.. (2014), 'Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins. .' Frontiers in Molecular Neuroscience. 10.3389/fnmol.2014.00027. " "
- Gross GG, Junge JA, Mora RJ, Kwon HB, Olson CA, Takahashi TT, Liman ER, Ellis-Davies GC, McGee AW, Sabatini BL, Roberts RW, Arnold DB.. (2013), 'Recombinant probes for visualizing endogenous synaptic proteins in living neurons. .' Neuron. 10.1016/j.neuron.2013.04.017. "