Human Mouse Rat
IHC IP WB
Synapse-Associated Protein 102, Disks large homolog 3(DLG3) or SAP102 MAGUK scaffold protein is encoded by the gene DLG3. SAP102 is a member of the MAGUK (membrane-associated guanylate kinase) protein family. SAP102 can bind to a number of adhesion molecules and receptors, including NMDA receptors and acts as a scaffold protein to mediate synaptic signaling. This protein plays a role in learning and memory and appears to be required for learning. Mutations in this gene have been associated with X-linked cognitive disability.
Fusion protein amino acids 1-120 of rat SAP102 (accession number Q62936); Human: 98% identity (117/120 amino acids identical); Mouse: 98% identity (118/120 amino acids identical)
No cross-reactivity against other MAGUK family membersPSD-95, SAP97, Chapsyn-110
TC Supernatant: AB_10671660
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.