Anti-RGS14 Antibody (N133/35)

Name: Anti-RGS14 Antibody
Brand: NeuroMab
SKU: 75-422
Price: 319.0 USD
Availability: InStock

Our Anti-RGS14 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N133/35. It detects human, mouse, and rat RGS14, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

$Immunoblot against crude rat brain membrane fractions (RBM) and extracts of COS cells transiently transfected with GFP-tagged rat RGS14 (rRGS14), Flag-tagged human RGS14 (hRGS14), GFP-tagged rat RGS12 (rRGS12) or untagged Kv2.1 plasmid probed with N133/35 (left) or N52A/42 (right) TC supe.$

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-422

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

RGS14

Target Description

RGS14 is a member of the RGS family (regulator of G-protein signaling) and is highly expressed in the prefrontal cortex. Hallmark domains of RGS14 include a RGS domain, two Raf-like Ras-binding domains and a GoLoco motif. RGS14 inactivates G protein α subunits. This protein has been implicated in Schizophrenia and Alzheimer’s disease.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N133/35

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Rgs14

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 1-544 (full-length) of rat RGS14 (accession number O08773) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2716259

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

ICC: 1:500

Conjugate

Unconjugated

Specificity

Does not cross-react with RGS12

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Regulator of G-protein signaling 14 (RGS14)

UniProt Details

UniProt (Human): O43566
UniProt (Immunogen Species): O08773

Product Specific References for Applications and Species

Immunocytochemistry: Mouse

Immunocytochemistry: Mouse
PMID	Dilution	Publication
34003113	1:300	Robert, V., et al. 2021. Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1. eLife, e63352.

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Anti-RGS14 Antibody (N133/35)

SKU: 75-422

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-RGS14 Antibody

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