Recombinant Human CXCL10 (IP-10)

Name: Recombinant Human CXCL10 (IP-10)
Brand: ImmunoChemistry Technologies
SKU: 6563
Price: 200.0 USD
Availability: InStock

The ELR-negative CXC chemokine CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. Human CXCL10 Recombinant Protein is purified CXCL10 (IP-10) produced in yeast.

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SKU: 6563

Volume: 5 µg

Variant

Price:

$200.00

Quantity:

Ships: 1-2 business days

Product Details

Scientific Background

C-X-C motif chemokine 10 (CXCL10), also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10, is a member of the C-X-C chemokine family and is closely related to two other CXC chemokines: CXCL9 and CXCL11. There have been 17 different C-X-C chemokines described in mammals that are subdivided into two categories: those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. The ELR-negative chemokine CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.

Format

Lyophilized

Protein Sequence

VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP (77)

Source

Yeast

Contents

Recombinant proteins produced in yeast

Usage Statement

For research use only. Not for use in diagnostic procedures.

Country of Origin

United States

Storage

-20°C

Shipping

Ships at ambient temperature, Domestic: Overnight Delivery; International: Priority Shipping

The Human IP-10/CXCL10 protein can be used in cell culture, as an IP-10/CXCL10 ELISA Standard, and as a Western Blot Control.

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Recombinant Human CXCL10 (IP-10)

SKU: 6563

Product Details

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