Human Mouse Rat
ICC IHC WB
RNA-Binding Motif Protein 17 or Splicing factor 45 is encoded by the gene RBM17. RBM17 is a component of the spliceosome complex and displays catalytic activity during mRNA splicing. RBM17 is involved in alternative splicing, resulting in different isoforms of a gene. RBM is also thought to play a role in DNA repair (Red: Chaouki et al 2006) RBM17 is widely expressed in the nucleus and important for development. Diseases associated with this gene include sickle cell anemia and forms of Ataxia 1.
Fusion protein amino acids 100-200 of human RBM17 (also known as RNA-binding motif protein 17, Splicing factor 45, 45 kDa-splicing factor, SPF45, accession number Q96I25); Mouse: 99% identity (100/101 amino acids identical); Rat: 99% identity (100/101 amino acids identical)
No cross-reactivity reported
TC Supernatant: AB_10672987
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.