Human Mouse Rat
Fusion protein amino acids 112-496 of human Pink1 (accession number NP_115785)
Mouse: 81% identity (312/385 amino acids identical)
Rat=82% identity (316/385 amino acids identical)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 220.127.116.11) (BRPK) (PTEN-induced putative kinase protein 1)
TC Supernatant: AB_10675457
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Okatsu K, Oka T, Iguchi M, Imamura K, Kosako H, Tani N, Kimura M, Go E, Koyano F, Funayama M, Shiba-Fukushima K, Sato S, Shimizu H, Fukunaga Y, Taniguchi H, Komatsu M, Hattori N, Mihara K, Tanaka K, Matsuda N.. (2012), 'PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. .' Nature Communications. 10.1038/ncomms2016. " "
- Zhou C, Huang Y, Shao Y, May J, Prou D, Perier C, Dauer W, Schon EA, Przedborski S.. (2008), 'The kinase domain of mitochondrial PINK1 faces the cytoplasm. .' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.0802814105. "