Pannexin 2 is encoded by the gene PANX2. PANX2 is a member of the pannexin family. PANX2 combines with pannexin 1 to form cell type-specific gap junctions with distinct properties. PANX2 is expressed in the eye, thyroid, prostate, kidney, liver, and central nervous system. Diseases associated with PANX2 include Oculodentodigital Dysplasia and Chronic Closed-Angle Glaucoma.
Fusion protein amino acids 11-664 (all but first 10 amino acids, encompassing extracellular and cytoplasmic domains) of rat Pannexin-2 (also known as Panx2 and Px2, accession number P60571); Mouse: 98% identity (645/657 amino acids identical); Human: 91% identity (564/615 amino acids identical); Less than 30% identity with Pannexin-1 and Pannexin-3
Does not cross-react with Pannexin-1 or Pannexin-3
TC Supernatant: AB_10673509
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.