Human Mouse Rat
ICC IHC WB
Synthetic peptide amino acids 2-18 (AAAIASSLIRQKRQARE) of human FHF2A (also known as Fibroblast growth factor homologous factor 2A, Fibroblast growth factor 13A and FGF13A, accession number Q92913)
Rat: 100% identity (17/17 amino acids identical)
Mouse: 94% identity (16/17 amino acids identical) >80% identity with FGF12A/FHF1A, FGF14A/FHF4A and FGF11A/FHF3A
Cross-reacts with FGF12A/FHF1A and FGF14A/FHF4A Does not cross-react with FGF13B/FHF2B
cross reacts with FGF12A/FHF1A and FGF14A/FHF4A
TC Supernatant: AB_10672416
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Barbosa C1,2, Xiao Y1,2, Johnson AJ1,2, Xie W3, Strong JA3, Zhang JM3, Cummins TR4,5,6.. (2017), 'FHF2 isoforms differentially regulate Nav1.6-mediated resurgent sodium currents in dorsal root ganglion neurons..' Pflugers Arch.. 10.1007/s00424-016-1911-9.
- Bosch MK1, Nerbonne JM1,2, Townsend RR2,3, Miyazaki H4, Nukina N4, Ornitz DM1, Marionneau C5.. (2016), 'Proteomic analysis of native cerebellar iFGF14 complexes..' Channels (Austin).. 10.1080/19336950.2016.1153203.
- Venkatesan K1, Liu Y2, Goldfarb M3.. (2014), 'Fast-onset long-term open-state block of sodium channels by A-type FHFs mediates classical spike accommodation in hippocampal pyramidal neurons..' J Neurosci.. 10.1523/JNEUROSCI.1271-14.2014.
- Dover K1, Solinas S, D'Angelo E, Goldfarb M.. (2010), 'Long-term inactivation particle for voltage-gated sodium channels..' J Physiol. . 10.1113/jphysiol.2010.192559.