When placing orders, please note whether your facility is currently receiving packages

Products: Primary Antibodies

Anti-NGL-2/LRRC4 Antibody (N50/36)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-084
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-084
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

Leucine Rich Repeat Containing 4 is encoded by the gene LRRC4. LRRC4 is a synaptic adhesion protein that regulates the formation of excitatory synapses through the recruitment of pre and postsynaptic proteins. LRRC4 organizes the lamina pathway-specific differentiation of dendrites, and plays an important role in auditory synaptic responses. LRRC4 is expressed in the brain. LRRC4 is significantly downregulated in primary brain tumors.

Immunogen:

Fusion protein amino acids 550-652 of mouse NGL-2 (accession number AAG60620); Human: 98% identity (101/103 amino acids identical); Rat: 99% identity (102/103 amino acids identical)

Cross Reactivity:

No cross-reactivity against NGL-1 or NGL-3

Protein Name(s):

NGL-2/LRRC4

Gene Name(s):

Lrrc4

Antibody Registry ID:

Purified: AB_2137614
TC Supernatant: AB_10672415


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

100 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.