Werner syndrome ATP-dependent helicase, WRN RecQ Like Helicase or DNA Helicase, RecQ-Like Type 3 is encoded by the gene WRN and is a member of the WRN RecQ Like Helicase family. WRN acts as a DNA helicase that is involved in DNA repair, replication, recombination and maintenance of DNA stability. WRN is a multifunctional enzyme with ATP dependent helicase activity, and is the only RecQ helicase member that has 3’ to 5’ exonuclease activity. WRN is expressed within the central nervous system and brain Diseases associated with this gene include Werner Syndrome and Medulloblastoma.
Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (also known as Sodium channel subunit beta-1 and Scn1b, accession number Q00954)
Mouse: 99% identity (146/147 amino acids identical)
Human: 97% identity (143/147 amino acids identical)
50% identity with Navbeta2 or Navbeta3
Does not cross-react with Navbeta2, Navbeta3 or Navbeta4
Sodium channel subunit beta-1
TC Supernatant: AB_2531891
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.