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Products: Primary Antibodies

Anti-Nav1.4 sodium channel Antibody (N255/38)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-424
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-424
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

Sodium channel subunit beta-1or Navbeta1 Na+ channel is encoded by SCN1B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. SCN1B has two splice variants. Navß1 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel inactivation. It is found expressed in brain, spinal cord, heart and skeletal muscle. Diseases associated with SCN1B include several types of epilepsy.

Immunogen:

Fusion protein amino acids 269-386 (Repeat I external pore between S5 and S6) of rat Nav1.4 (also known as Voltage-gated sodium channel subunit alpha Nav1.4, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Scn4a, SkM1 and Mu-1, accession number P15390) Mouse: 96% identity (113/118 amino acids identical)
Human: 85% identity (106/124 amino acids identical)
60% identity with Nav1.2, Nav1.3 and other Nav1 channels

Protein Name(s):

Sodium channel protein type 4 subunit alpha (Mu-1) (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)

Gene Name(s):

Scn4a

Antibody Registry ID:

Purified: AB_2716260
TC Supernatant: AB_2531890


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

>200 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.