Human Mouse Rat
IHC IP WB
Matrix Metallopeptidase 9 is encoded by the gene MMP9. MMP9 is a member of the peptidase M10A family. MMP9 may play a role in local proteolysis of the extracellular matrix, leukocyte migration, and bone osteoclastic resorption. MMP9 cleaves type IV and V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. MMP9 is expressed in neutrophils. Diseases associated with MMP9 include Metaphyseal Anadysplasia 2 and Metaphyseal Anadysplasia.
Fusion protein amino acids 1-708 (full-length) of rat MMP9 (also known as matrix metalloproteinase 9, 92 kDa type IV collagenase, 92 kDa gelatinase, gelatinase B and GELB, accession number P50282); Human: 68% identity (482/708 amino acids identical); Mouse: 74% identity (548/731 amino acids identical); Less than 50% identity with MMP2
No cross-reactivity reported
TC Supernatant: AB_10672974
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
92 and 82 kDa(Pro and Active forms)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.