Products: Primary Antibodies

Anti-Kv7.2/KCNQ2 K+ channel Antibody (N26A/23)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-079
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-079
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

WB

Target Description:

Potassium voltage-gated channel subfamily Q member 2 is encoded by the gene KCNQ2. KCNQ2 is a member of the potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.2/KCNQ2 sub-subfamily. KCNQ2 associates with KCNQ3 to form a potassium channel with nearly identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness of synaptic inputs. KCNQ2 is expressed in the brain and spinal cord. Diseases associated with KCNQ2 include Epileptic Encephalopathy, Early Infantile, 7 and Seizures, Benign Familial Neonatal 1.

Immunogen:

Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (also known as Potassium voltage-gated channel subfamily KQT member 2 or KvLQT2, Kv7.2 and KQT-like 2, accession number O43526); Rat: 96% identity (56/58 amino acids identical); Mouse: 96% identity (56/58 amino acids identical)

Cross Reactivity:

No cross-reactivity reported

Protein Name(s):

Kv7.2/KCNQ2 K+ channel

Gene Name(s):

KCNQ2

Antibody Registry ID:

Purified: AB_2131704
TC Supernatant: AB_10673164


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

95 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.