Human Mouse Rat
Potassium voltage-gated channel subfamily Q member 2 is encoded by the gene KCNQ2. KCNQ2 is a member of the potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.2/KCNQ2 sub-subfamily. KCNQ2 associates with KCNQ3 to form a potassium channel with nearly identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness of synaptic inputs. KCNQ2 is expressed in the brain and spinal cord. Diseases associated with KCNQ2 include Epileptic Encephalopathy, Early Infantile, 7 and Seizures, Benign Familial Neonatal 1.
Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (also known as Potassium voltage-gated channel subfamily KQT member 2 or KvLQT2, Kv7.2 and KQT-like 2, accession number O43526); Rat: 96% identity (56/58 amino acids identical); Mouse: 96% identity (56/58 amino acids identical)
No cross-reactivity reported
Kv7.2/KCNQ2 K+ channel
TC Supernatant: AB_10673164
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.