Human Mouse Rat
IHC IP WB
Synthetic peptide amino acids 175-192 (GDEAGDDERELALQRLGP) of rat Kv3.4 (also known as potassium voltage-gated channel subfamily C member 4 and Raw3, accession number Q63734)
Mouse: 100% identity (18/18 amino acids identical)
Human: 94% identity (17/18 amino acids identical)
Potassium voltage-gated channel subfamily C member 4 (Raw3) (Voltage-gated potassium channel subunit Kv3.4)
TC Supernatant: AB_10673969
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
70 kDa(100 kDa in brain due to glycosylation)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Dufour MA, Woodhouse A, Goaillard JM.. (2014), 'Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development. .' Journal of Neuroscience Research. 10.1002/jnr.23382. " "
- DiFranco M, Quinonez M, Vergara JL.. (2012), 'The delayed rectifier potassium conductance in the sarcolemma and the transverse tubular system membranes of mammalian skeletal muscle fibers. .' The Journal of General Physiology. 10.1085/jgp.201210802. " "
- Duan KZ, Xu Q, Zhang XM, Zhao ZQ, Mei YA, Zhang YQ.. (2012), 'Targeting A-type K(+) channels in primary sensory neurons for bone cancer pain in a rat model. .' Pain. 10.1016/j.pain.2011.11.020. " "
- Sun W, Maffie JK, Lin L, Petralia RS, Rudy B, Hoffman DA.. (2011), 'DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. .' Neuron. 10.1016/j.neuron.2011.08.008. " "
- Gross C, Yao X, Pong DL, Jeromin A, Bassell GJ.. (2011), 'Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. .' Journal of Neuroscience. 10.1523/JNEUROSCI.6661-10.2011. " "
- Pacheco Otalora LF, Skinner F, Oliveira MS, Farrell B, Arshadmansab MF, Pandari T, Garcia I, Robles L, Rosas G, Mello CF, Ermolinsky BS, Garrido-Sanabria ER.. (), 'Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats. .' Brain Research. 10.1016/j.brainres.2010.10.047. " "
- Gittis AH, Moghadam SH, du Lac S.. (2010), 'Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents. .' Journal of Neurophysiology. 10.1152/jn.00378.2010. "