Anti-Kv3.2 Potassium Channel Antibody (N410/17)

Name: Anti-Kv3.2 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-397
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Kv3.2 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N410/17. It is KO validated, detects human, mouse, and rat Kv3.2 potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat hippocampus immunohistochemistry.

Immunoblot against crude membranes from adult rat brain (RBM), mouse brain (MBM) and wild-type (WT) and Kv3.2 knockout (KO) mouse brains probed with N410/17 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Bernardo Rudy (NYU School of Medicine).

Whole brain immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-397

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Kv3.2 potassium channel

Target Description

Potassium voltage-gated channel subfamily C member 2 or Kv3.2 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.2 is primarily expressed in brain and found in the cortex and hippocampus. It has also been detected in the thalamus and caudate nucleus. Kv3.2 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with KCNC2 include Spinocerebellar Ataxia 13 and Episodic Ataxia, Type 2

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N410/17

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc2

Molecular Weight

80-100 kDa (varies due to post-translational modifications)

Antigen

Fusion protein amino acids 474-613 (cytoplasmic C-terminus) of rat Kv3.2a (accession number P22462-3) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491084

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

IHC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily C member 2 (Potassium channel voltage-gated Shaw-related subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel subunit Kv3.2)

UniProt Details

UniProt (Human): Q96PR1
UniProt (Immunogen Species): P22462-3

Product Specific References for Applications and Species

Immunhistochemistry: Human

Immunohistochemistry: Human
PMID	Dilution	Publication
34180393	1:250	Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels. Elife, e66491.

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Anti-Kv3.2 Potassium Channel Antibody (N410/17)

SKU: 75-397

Product Details

Product Specific References for Applications and Species

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