Anti-Kv1.1 K+ Channel Antibody (K20/78)
Our Anti-Kv1.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K20/78. It is KO validated, detects finch, human, mouse, rabbit, and rat Kv1.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Adult rat brain hippocampus immunohistochemistry.
Finch, Human, Mouse, Rabbit, Rat
ICC, IHC, IP, WB
Mouse
KO Validated
Product Specific References for Applications and Species
- Affinity Purification: Mouse
- Immunocytochemistry: Human | Mouse | Rabbit | Rat
- Immunohistochemistry: Human | Mouse | Rat | Zebra Finch
- Immunoprecipitation: Mouse
- Western Blot: Human | Mouse | Rat
- Additional Publications: Unspecified
| Affinity Purification: Mouse | ||
| PMID | Dilution | Publication |
| 22067099 | not listed | Bildl, W., et al. 2012. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications.. Molecular & Cellular Proteomics, . |
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 31586945 | 1:50 | Verdura, E., et al. 2020. Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia. . Journal of Medical Genetics, 132-137. |
| 23774215 | not listed | Lallet-Daher, H., et al. 2013. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.. Cancer Research, 5253-5265. |
| 20580615 | 1:50 | Lai, M., et al. 2010. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series.. The Lancet Neurology, 776-785. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 33689679 | 1:10 | Chang, K.J., et al. 2021. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. . Elife, e64456. |
| 33168717 | not listed | Cho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. . Proceedings of the National Academy of Sciences, 29937-29947. |
| 24367293 | 15 μg/ml | Kirchheim, F., et al. 2013. Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy.. Frontiers in Neuroscience, 248. |
| 22641786 | 1:1000 | Glasscock, E., et al. 2012. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels.. The Journal of Physiology, 3913-3926. |
| 21632923 | not listed | Buttermore, E.D., et al. 2011. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.. Journal of Neuroscience, 8013-24. |
| 21233214 | 1:1000 | Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372. |
| Immunocytochemistry: Rabbit | ||
| PMID | Dilution | Publication |
| 20720182 | not listed | Large, R.J., et al. 2010. Ionic currents in intimal cultured synoviocytes from the rabbit.. American Journal of Physiology-Cell Physiology, C1180-C1194. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 31164806 | 1:100 | Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. . Frontiers in Cellular Neuroscience, 222. |
| 23836929 | not listed | Sosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69. |
| 21357749 | not listed | Vacher, H., et al. 2011. Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.. The Journal of Biology, 813-24. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 29564531 | 5-20ug/ml | Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 34676525 | 1:1000 | Miwa, H., et al. 2021. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum.. The Cerebellum, 1-15. |
| 33168717 | not listed | Cho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. . Proceedings of the National Academy of Sciences, 29937-29947. |
| 28712654 | 1:500 | Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655. |
| 26269632 | not listed | Smith, K.E., et al. 2015. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice.. Journal of Neuroscience, 11221-11232. |
| 24687876 | 1:250 | King, C.H., et al. 2014. Kv7.2 regulates the function of peripheral sensory neurons.. Journal of Comparative Neurology, 3262-3280. |
| 23090990 | 1:1000 | Nguyen, H.M., et al. 2012. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.. Proceedings of the National Academy of Science of the United States of America, 18577-18582. |
| 21958379 | not listed | Duflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, 1-19. |
| 21676499 | 1:100 | Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623. |
| 21632949 | 1:500 | Hirtz, J.J., et al. 2011. Cav1.3 calcium channels are required for normal development of the auditory brainstem.. Journal of Neuroscience, 8280-94. |
| 20575068 | 1:100 | Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20. |
| 21233214 | 1:1000 | Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 34799447 | 1:100 | Zbili, M., et al. 2021. Homeostatic regulation of axonal Kv1. 1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. . Proceedings of the National Academy of Sciences, e2110601118. |
| 32345673 | 1:300 | Housley, S.N., et al. 2020. Cancer Exacerbates Chemotherapy-Induced Sensory NeuropathyCancer Exacerbates Chemotherapy-Induced Sensory Neuropathy. . Cancer research, 2940-2955. |
| 24723263 | 1:100 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99. |
| 24523557 | 1:100 | Tagoe, T., et al. 2014. Auditory nerve perinodal dysmyelination in noise-induced hearing loss. Journal of Neuroscience, 2684-2688. |
| 23318870 | not listed | Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91. |
| 22473424 | not listed | Huang, C.Y., et al. 2012. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.. Journal of Comparative Neurology, 3650-3672. |
| 21734302 | 1:200 | Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114. |
| Immunohistochemistry: Zebra Finch | ||
| PMID | Dilution | Publication |
| 31937558 | 1:500 | Chen, A.N., et al. 2020. Experience-and sex-dependent intrinsic plasticity in the zebra finch auditory cortex during song memorization. . Journal of Neuroscience, 2047-2055. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 28712654 | not listed | Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 29564531 | not listed | Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671. |
| 27872049 | 1:2000 | Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 32130108 | 1:1000 | Siems, S.B., et al. 2020. Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.. Elife, e51406. |
| 33157003 | not listed | Kuijpers, M., et al. 2021. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron, 299-313. |
| 32437528 | not listed | Ramberger, M., et al. 2020. Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms. Brain, 1731-1745. |
| 30586380 | not listed | Favaro, P.D., et al. 2018. An opposing function of paralogs in balancing developmental synapse maturation. Plos Biology, e2006838. |
| 29564531 | not listed | Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671. |
| 29476105 | 1:1000 | Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568. |
| 28712654 | 1:500 | Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655. |
| 26269648 | 1:400 | Kole, M.J., et al. 2015. Selective loss of presynaptic potassium channel clusters at the cerebellar basket cell terminal pinceau in adam11 mutants reveals their role in ephaptic control of purkinje cell firing. . Journal of Neuroscience, 11433-11444. |
| 22385959 | not listed | Huang, Y.W., et al. 2012. Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis.. Cell, 933-46. |
| 22131424 | 1:500 | Kaphzan, H., et al. 2011. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.. Journal of Neuroscience, 17637-48. |
| 21943606 | 1:1000 | Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-15. |
| 20575068 | not listed | Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 23792947 | 1:200 | Zhao, X., et al. 2013. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.. Nature Neuroscience, 1024-1031. |
| 23536771 | 1:1000 | Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808. |
| 23318870 | 1:10 | Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91. |
| 23066017 | 1:2000 | Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 25707359 | Chen, N., et al. 2015. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. . Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 827-833. | |
| 22492029 | Buttermore, E.D., et al. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development.. Journal of Neuroscience, 4724-4742. | |
| 22291039 | Ivanovic, A., et al. 2012. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.. The Journal of Biology, 337-44. | |
| 21906755 | Loukaides, P., et al. 2012. Morvan''s syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex. Journal of the Neurological Sciences, 52-56. | |
| 21220016 | Giacomini, C., et al. 2011. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice.. Neurobiology of Disease, 73-84. | |
| 20392939 | Glasscock, E., et al. 2010. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.. Journal of Neuroscience, 5167-5175. | |
| 20133599 | Fukata, Y., et al. 2010. Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy. . Proceedings of the National Academy of Sciences, 3799-3804. | |
| 20089912 | Ogawa, Y., et al. 2010. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. . Journal of Neuroscience, 1038-1048. | |
| 19903818 | van der Wijst, J., et al. 2010. Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia.. The Journal of Biological Chemistry, 171-178. | |
| 19818338 | Toyoshima, M., et al. 2009. Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse.. Developmental Biology, 192-200. | |
| 19307729 | Glaudemans, B., et al. 2009. A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia.. Journal of Clinical Investigation, 936-942. | |
| 19091962 | Miller, M.N., et al. 2008. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits.. Journal of Neuroscience, 13716-13726. | |
| 17651419 | Wenzel, H.J., et al. 2007. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.. Epilepsia, 2023-2046. | |
| 17185748 | Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914. | |
| 17145502 | Gu, C., et al. 2006. The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.. Neuron, 803-816. | |
| 18684900 | Pineda, R.H, et al. 2008. Kv1 potassium channel complexes in vivo require Kvβ2 subunits in dorsal spinal neurons. . Journal of neurophysiology, 2125-2136. | |
| 22886464 | Engelhardt, M., et al. 2013. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.. Brian Structure and Function, 1005-1016. | |