Anti-Kir3.3 Channel Antibody (N455/15)

Name: Anti-Kir3.3 Channel Antibody
Brand: NeuroMab
SKU: 75-445
Price: 319.0 USD
Availability: InStock

Our Anti-Kir3.3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N455/15. It is KO validated, detects human, mouse, and rat Kir3.3, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunofluorescence staining of brain sections from adult Kir3.3 wild-type (WT) and knockout (KO) mouse cortex with N455/15 (Kir3.3, red) and K89/34 (Kv2.1, blue) TC supe. Tissue courtesy of Candice Contet (The Scripps Research Institute)..

Immunofluorescence staining of brain sections from adult Kir3.3 wild-type (WT) and knockout (KO) mouse cerebellum with N455/15 (Kir3.3, red) and K89/34 (Kv2.1, blue) TC supe. Tissue courtesy of Candice Contet (The Scripps Research Institute)..

Immunofluorescence staining of brain sections from adult Kir3.3 wild-type (WT) and knockout (KO) mouse cortex with N455/15 (Kir3.3, red) and K89/34 (Kv2.1, blue) TC supe. Tissue courtesy of Candice Contet (The Scripps Research Institute)..

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-445

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Kir3.3

Target Description

Potassium inwardly rectifying channel subfamily J member 9 is encoded by the gene KCNJ9. KCNJ9 is a member of the inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ9 subfamily. KCNJ9 is an integral membrane protein and inward-rectifier type potassium channel, which has a greater tendency to allow potassium to flow into the cell rather than out of the cell. KCNJ9 is controlled by G-proteins and associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. KCNJ9 is expressed in the brain and skeletal muscle. Diseases associated with KCNJ9 include Pendred Syndrom and Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, and Electrolyte Imbalance.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N455/15

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnj9 Girk3

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-21 and 341-393 (fusion of cytoplasmic N- and C-termini) of mouse Kir3.3 (accession number P48543) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2686912

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Inward rectifier K(+) channel Kir3.3 (Potassium channel, inwardlyrectifying subfamily J member 9) (G protein-activated inward rectifier potassium channel 3) (Kcnj9) (Girk3)

UniProt Details

UniProt (Human): Q92806
UniProt (Immunogen Species): P48543

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Anti-Kir3.3 Channel Antibody (N455/15)

SKU: 75-445

Product Details

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