Fusion protein amino acids 1-359 (full-length) of mouse Iduna (also known as RING finger protein 146, RNF146 and Dactylidin, accession number Q9CZW6)
Rat: 93% identity (335/357 amino acids identical)
Human: 92% identity (333/359 amino acids identical)
E3 ubiquitin-protein ligase RNF146 (EC 126.96.36.199) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)
TC Supernatant: AB_10675284
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Xu H, Luo P, Zhao Y, Zhao M, Yang Y, Chen T, Huo K, Han H, Fei Z.. (2013), 'Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos). .' Cellular Signalling. 10.1016/j.cellsig.2013.01.006. " "
- Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM.. (2011), 'Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. .' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1108799108. "