Anti-Histone H2A.Z/V Antibody (N310/21)

Name: Anti-Histone H2A.Z/V Antibody
Brand: NeuroMab
SKU: 75-276
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Histone H2A.Z/V mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N310/21. It detects human, mouse, and rat Histone H2A.Z/V, and is purified by Protein A chromatography. It is great for use in DB, ELISA.

Serial dilutions of BSA-conjugated target and non-target peptides dotted onto membrane and probed with N310/21 TC supe (left) and a rabbit polyclonal antibody control (right).

Species Reactivity

Human, Mouse, Rat

Applications

ELISA

Host Species

Mouse

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Data Sheet

SKU: 75-276

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Histone H2A.Z/V

Target Description

H2A.Z Variant Histone 1 is encoded by the gene H2AZ1. H2AZ1 is a member of the histone H2A family. H2AZ1 is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic fatality. H2AZ1 is expressed in 239 organs with the highest levels in the myometrium. Diseases associated with H2AZ1 include testicular spermatocytic seminoma.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N310/21

Isotype

IgG1

Applications

ELISA

Host Species

Mouse

Gene Name

H2AFZ H2AZ

Molecular Weight

13 kDa

Antigen

Synthetic peptide amino acids 116-128 (KSLIGKKGQQKTV) of human Histone H2A.Z (accession number P0C0S5) produced recombinantly in E. Coli.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11000054

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Cross-reactivity against Histone H2A.V not yet determined

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Histone H2A.Z (H2A/z)

UniProt Details

UniProt (Human): P0C0S5
UniProt (Immunogen Species): P0C0S5

Satterlee JS1, Beckel-Mitchener A, McAllister K, Procaccini DC, Rutter JL, Tyson FL, Chadwick LH. (2015), 'Community resources and technologies developed through the NIH Roadmap Epigenomics Program..' Methods Mol Biol. . 10.1007/978-1-4939-1804-1_2.

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Anti-Histone H2A.Z/V Antibody (N310/21)

SKU: 75-276

Product Details

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