Human Mouse Rat
ICC IHC WB
C-fos belongs the Fos family. Other members include FosB, Fra-1, Fra-2. c-fos binds to JUN/AP1 transcription factor. C-Fos is expressed in placental tissue, fetal liver, developing bone, developing central nervous system, and adult bone marrow. It is expressed in the nucleus and in the endoplasmic reticulum. c-Fos is has a role in signal transduction, cell proliferation, differentiation, and apoptosis. C-Fos is overexpressed in many cancers.
Fusion protein amino acids 1-377 (full-length) of human FOS (also known as Proto-oncogene c-Fos, G0/G1 switch regulatory protein 7 and G0S7, accession number P01100)
Rat: 94% identity (355/377 amino acids identical)
Mouse: 94% identity (353/377 amino acids identical)
<50% identity with FOSL2
Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when tested by Western Blot.