Fibroblast growth factor 14, FHF4 or FGF14 is encoded by FGF14. FHF4 is a member of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage fated sodium channels (Nav channels) and are thought to be involved in nervous system development. FGF14 in found in both the hippocampus and the cerebellum localizes to the axon initial segment. Diseases associated with FGF14 include Spinocerebellar Ataxia and Autosomal Dominant Cerebellar Ataxia.
Fusion protein amino acids 1-252 (full-length) of mouse FGF14b (also known as fibroblast growth factor homologous factor 4b or FHF4b, accession number O89096); Human: 98% identity (247/252 amino acids identical); Mouse: 100% identity (252/252 amino acids identical)
Cross-reacts with FGF14a and FGF14b Does not cross-react with FGF11, FGF12 or FGF13
TC Supernatant: AB_10671703
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.