Anti-FGF12/FHF1 Antibody (N94/17)

Name: Anti-FGF12/FHF1 Antibody
Brand: NeuroMab
SKU: 75-135
Price: 319.0 USD
Availability: InStock

Our Anti-FGF12/FHF1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N94/17. It detects human, mouse, and rat FGF12/FHF1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP.

Transfected cell immunofluorescence: COS cells expressing GFP-tagged FGF12b/FHF1b. Red = N94/17, Green = GFP, Blue = Hoechst nuclear stain.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-135

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

FGF12/FHF1

Target Description

Fibroblast growth factor 12, FHF1 or FGF12 is encoded by the gene FGF12. FHF1 is a member of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage fated sodium channels (Nav channels) and are thought to be involved in nervous system development. FGF12 has been found to be expressed in the brain, eye and testis. Diseases associated with FGF12 include Early Infantile Epileptic Encephalopathy, Ebstein anomaly and Autosomal Dominant Deafness.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N94/17

Isotype

IgG1

Applications

ICC, IHC, IP

Host Species

Mouse

Gene Name

FGF12 FGF12B FHF1

Molecular Weight

27 kDa

Antigen

Fusion protein amino acids 1-243 (full-length) of human FGF12a (accession number P61328) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2278408

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.61

Dilution Ranges

WB: 1:200
IHC: 1:100

Conjugate

Unconjugated

Specificity

Cross-reacts with FGF12b/FHF1bDoes not cross-react with FGF11/FHF3, FGF13/FHF2 or FGF14/FHF4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor)

UniProt Details

UniProt (Human): P61328
UniProt (Immunogen Species): P61328

Product Specific References for Applications and Species

Immunocytochemistry: Human
Immunohistochemistry: Rat
Western Blot: Rat

Immunocytochemistry: Human
PMID	Dilution	Publication
35064871	1:200	Fularczyk, N., et al. 2022. A Learning Based Framework for Disease Prediction from Images of Human-Derived Pluripotent Stem Cells of Schizophrenia Patients.. Neuroinformatics, 1-11.

Immunohistochemistry: Rat
PMID	Dilution	Publication
25724910	1:100	Wildburger, N.C., et al. 2015. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.. Molecular & Cellular Proteomics, 1288-300.

Western Blot: Rat
PMID	Dilution	Publication
25724910	1:100	Wildburger, N.C., et al. 2015. Quantitative proteomics reveals protein-protein interactions with fibroblast growth factor 12 as a component of the voltage-gated sodium channel 1.2 (nav1.2) macromolecular complex in Mammalian brain.. Molecular & Cellular Proteomics, 1288-300.

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Anti-FGF12/FHF1 Antibody (N94/17)

SKU: 75-135

Product Details

Product Specific References for Applications and Species

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