Human Mouse Rat
Endoribonuclease Dicer or Dicer 1, Ribonuclease III is encoded by the gene DICER1. DICER1 acts as a double stranded (ds) ribonuclease and plays a role in short post transcriptional gene silencing. DICER1 cleaves full length dsRNA and miRNA into smaller moleclues 21-23 nucleotides in length, called siRNAs and microRNAs. Dicer1 is expressed in a variety of tissues, including brain. Diseases associated with this gene include Pleuropulmonary Blastoma, Glow Syndrome and Wilms Tumor.
Fusion protein amino acids 1638-1899 of mouse Endoribonuclease Dicer (also known as Dicer1, DCR, DCR-1, Double-strand-specific ribonuclease, Helicase with RNase motif, HERNA, Helicase MOI and KIAA0928, accession number Q8R418); Human: 99% identity (257/262 amino acids identical); Rat: 99% identity (257/262 amino acids identical)
No cross-reactivity reported
Dicer1 Dicer Mdcr
TC Supernatant: AB_10673275
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.