Products: Primary Antibodies
PRODUCT OPTIONS
Catalog # | Option | Volume | Concentration | Price* | |
---|---|---|---|---|---|
Catalog # 75-113 |
Option Purified |
Volume 100 µL |
Concentration 1 mg/mL |
Price $269.00 |
|
Catalog # 73-113 |
Option TC Supernatant |
Volume 5 mL |
Concentration Lot dependent |
Price $269.00 |
Overview
NeuroMab
Monoclonal
Mouse
IgG2a
Human Mouse Rat
IHC IP WB
Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (also known as voltage-dependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732)
Mouse: 94% identity (16/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical)
No cross-reactivity against Cav1.2
Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)
Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2
Purified: AB_2069388
TC Supernatant: AB_10672112
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
250 kDa
Quality Control
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
-
"
- Perissinotti PP, Ethington EA, Almazan E, Martínez-Hernández E, Kalil J, Koob MD, Piedras-Rentería ES.. (2015), 'Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice. .' Frontiers in Neuroscience. 10.3389/fncel.2014.00444. " "
- Lu L, Sirish P, Zhang Z, Woltz RL, Li N, Timofeyev V, Knowlton AA, Zhang XD, Yamoah EN, Chiamvimonvat N.. (), 'Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3. .' The Journal of Biological Chemistry. 10.1074/jbc.M114.586883. " "
- Perissinotti PP, Ethington EG, Cribbs L, Koob MD, Martin J, Piedras-Rentería ES.. (2014), 'Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density. .' Cell Calcium. 10.1016/j.ceca.2014.03.002. " "
- Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ.. (2013), 'Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. .' Journal of Neuroscience. 10.1523/JNEUROSCI.5311-12.2013. " "
- Zou J, Lee A, Yang J.. (), 'The expression of whirlin and Cav1.3α₁ is mutually independent in photoreceptors. .' Vision Research. 10.1016/j.visres.2012.07.020. " "
- Yamasaki S, Hasegawa A, Hojyo S, Ohashi W, Fukada T, Nishida K, Hirano T.. (2012), 'A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave. .' PLoS One. 10.1371/journal.pone.0039654. " "
- Comerota AJ. (2011), 'Invited commentary. .' Journal of Vascular Surgery. 10.1016/j.jvs.2011.06.017. " "
- Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD.. (2012), 'Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. .' Journal of Clinical Investigation. 10.1172/JCI58227. " "
- Hettiarachchi NT, Parker A, Dallas ML, Pennington K, Hung CC, Pearson HA, Boyle JP, Robinson P, Peers C.. (2009), 'alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells. .' Journal of Neurochemistry. 10.1111/j.1471-4159.2009.06411.x. " "
- Abiria SA, Colbran RJ.. (2010), 'CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. .' Journal of Neurochemistry. 10.1111/j.1471-4159.2009.06436.x. "