Human Mouse Rat
IHC IP WB
Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.
Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (also known as voltage-dependent L-type calcium channel subunit alpha-1D, RAT brain class D and RBD, accession number P27732); Mouse: 94% identity (16/17 amino acids identical); Human: 88% identity (15/17 amino acids identical)
No cross-reactivity against Cav1.2
Cav1.3 Ca2+ channel
Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2
TC Supernatant: AB_10672112
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.