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Products: Primary Antibodies

Anti-CASK Antibody (K56A/50)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-000
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-000
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat Xenopus Zebrafish

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC IP WB

Target Description:

Calcium/Calmodulin-Dependent Serine Protein Kinase or CASK scaffolding protein is encoded by the gene CASK. CASK is a member of the MAGUK (membrane-associated guanylate kinase) protein family. CASK is a a calcium/calmodulin-dependent serine protein kinase. CASK is found in many different tissues including kidney, lung, liver and brain. In the brain, CASK protein is located at synapses. CASK acts as a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Mutations in this gene are associated with FG syndrome 4, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability.

Immunogen:

Fusion protein amino acids 318-415 of rat CASK/Lin2 (accession number Q62915); Human: 100% identity; Mouse=100% identity

Cross Reactivity:

No cross-reactivity reported

Protein Name(s):

CASK

Gene Name(s):

CASK LIN2

Antibody Registry ID:

Purified: AB_2068730
TC Supernatant: AB_10671954


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

100 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.