Human Mouse Rat
IHC IP WB
Fusion protein amino acids 45-167 (entire extracellular domain) of mouse BKBeta4 (accession number NP_067427)
Rat: 100% identity (123/123 amino acids identical)
Human: 95% identity (117/123 amino acids identical)
No cross-reactivity against BKBeta1, BKBeta2 or BKBeta3
Calcium-activated potassium channel subunit beta-4 (BK channel subunit beta-4) (BKbeta4) (Calcium-activated potassium channel, subfamily M subunit beta-4) (Charybdotoxin receptor subunit beta-4) (K(VCA)beta-4) (Maxi K channel subunit beta-4) (Slo-beta-4)
TC Supernatant: AB_10675133
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ.. (2013), 'Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. .' The Journal of Biological Chemistry. 10.1074/jbc.M113.461830. " "
- Zhang XL, Mok LP, Lee KY, Charbonnet M, Gold MS.. (2012), 'Inflammation-induced changes in BK(Ca) currents in cutaneous dorsal root ganglion neurons from the adult rat. .' Molecular Pain. 10.1186/1744-8069-8-37. " "
- Shruti S, Urban-Ciecko J, Fitzpatrick JA, Brenner R, Bruchez MP, Barth AL.. (2012), 'The brain-specific Beta4 subunit downregulates BK channel cell surface expression. .' PLoS One. 10.1371/journal.pone.0033429. "